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G-protein-gated inwardly rectifying K + (GIRK) channels play a key role in maintaining resting membrane potengirktial, cell excitability and inhibitory neurotransmission.

G protein-gated inwardly rectifying potassium (GIRK) channels hyperpolarize neurons in response to activation of many different G protein-coupled receptors and thus control the excitability of neurons through GIRK-mediated self-inhibition, slow synaptic potentials and volume transmission.

Four G protein gated inwardly-rectifying potassium (GIRK) channel subunits have been identified in mammals: GIRK1, GIgirkRK2, GIRK3, and GIRK4. The GIRK subunits come together to form GIRK ion channels.

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